While in the LSD-sure crystal structure, the facet chain from the lid residue L209EL2 types comprehensive hydrophobic contacts with the two LSD and bordering residues in TMs III, IV, and V (Determine 4C). If the lid moved apart to expose the binding pocket in simulation, several of these contacts broke. https://bookmarksystem.com/story19417315/the-lsd-crystal-diaries