Abstract We introduce Promoter-Enhancer-Guided Interaction Networks (PENGUIN). a method for studying protein-protein interaction (PPI) networks within enhancer-promoter interactions. PENGUIN integrates H3K27ac-HiChIP data with tissue-specific PPIs to define enhancer-promoter PPI networks (EPINs). We validated PENGUIN using cancer (LNCaP) and benign (LHSAR) prostate cell lines. https://www.markbroyard.com/best-grab-sukin-hydrating-body-lotion-250ml-fashion-save-extra/