Below problems of low CB1R density, THC antagonises endogenous agonists possessing better receptor efficacy than THC19. THC also allosterically modulates opioid receptors20, which can present extra oblique routes for altering dopamine transmission21. Moreover, THC has psychoactive metabolites with CB1R affinity, more complicating the analyses of receptor binding studies22. The psychoa... https://charliemmsyd.answerblogs.com/33227625/the-5-second-trick-for-endocannabinoid-system