Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals in the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactions, that ... https://ruhollahe197bir4.theideasblog.com/profile